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Published on: December 18, 2013
Clinical translation of salivary MicroAge for understanding the oral-systemic connection in healthy longevity
Tongjun Guo1, Yixuan Chen1, Yuehan Yu1
1Fifth Clinical Division, National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, School and Hospital of Stomatology, Peking University, Beijing, China.
Abstract:
The oral-systemic connection, salivary microbiome, and healthy longevity are increasingly recognized as biologically interconnected. This review summarizes lifespan changes in the salivary microbiome, its links to age-related systemic diseases, and recent progress in salivary MicroAge modeling. It further highlights advances in data preprocessing, feature engineering, and artificial intelligence-based prediction, while emphasizing the importance of standardization, generalizability, and biological interpretability for clinical translation. Overall, salivary MicroAge may provide a noninvasive and interpretable framework for biological aging assessment and healthier aging.
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