Artificial intelligence-supported therapeutic interventions for autism spectrum disorder: a systematic review

The increased prevalence of ASD has generated a pressing demand for flexible therapeutic and educational tools. AI has been suggested as a potential bridge to this gap, but the translation from a model to a clinical application necessitates rigorous assessment. The purpose of the present review is to compile and examine the existing literature to demonstrate AI interventions that have advanced from a proposed model to being used with human participants.

We systematically searched five databases (Embase, PubMed, ScienceDirect, IEEE Xplore, Web of Science; Jan 2016-Dec 2025) for AI-based ASD interventions. Two reviewers independently assessed eligibility. Inclusion criteria were as followed: (1) participants with confirmed ASD diagnoses; (2) an intervention sample size of N ≥ 6; (3) AI as a central therapeutic, educational, or rehabilitative component; and (4) multi-session protocols with specified timeframes. Study types ranged from system development and feasibility trials to RCTs.

14 studies met inclusion criteria. AI (e.g. robotics, VR, and wearables) functioned as a social mediator, improving social-emotional outcomes (e.g., ADOS, SRS scores) by reducing cognitive load. Significant mechanisms included real-time task adaptation and precise behavioral monitoring via e.g. eye-tracking. However, significant heterogeneity was observed in intervention dosage (median 4-12 hours). Most studies were limited by small, male-dominated samples (N < 20) and a total absence of adult participants.

Based on the findings, AI seems highly promising for patient-specific ASD therapy via proactive, data-driven scaffolding. In order to move toward implementation of AI in ASD care, more RCTs and crucial augmentation of representation gaps concerning adult and female ASD phenotype studies are required.