Primary Hepatic Lymphoma with Hepatocellular Carcinoma: A Case Report

This case report highlights the diagnostic challenges associated with PHL and outlines corresponding diagnostic strategies, underscoring the importance of clinicians being vigilant for PHL in patients with HCC, particularly when clinical presentations and imaging features are atypical. Instead of making a decision based only on a positive ICG result, it is advised that clinicians thoroughly assess the features of the newly discovered lesions found through ICG imaging during the procedure, the patient's general condition, and the surgical risks before deciding whether to resect them. We conducted a retrospective analysis of a confirmed case of PHL complicated by HCC. indicates that even when HCC is suspected, the possibility of PHL should not be ruled out when diagnosing liver lesions; therefore, active screening is necessary. ICG imaging can serve as an adjunctive tool to improve the detection rate of lesions during surgery; however, its clinical value is limited for small-volume lesions that are not considered for surgical resection.