Related Experiment Video
Updated: Sep 14, 2026

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
Published on: June 13, 2025
KD-GAG: Knowledge-distilled graph-augmented generation via preference-aware subgraph pruning
Long Zhao1, Yin Xu2, Yanyan Wang2
1University of Science and Technology of China, School of Computer Science and Technology, No.100, Fuxing Road, High tech Zone, Hefei, 230026, Anhui, China; GuoChuang Cloud Technology Ltd., Innovation & Research Institute, No.355 Wenqu Road, High tech Zone, HeFei, Anhui, 230031, China.
Abstract:
Retrieval-Augmented Generation (RAG) methods that integrate external knowledge sources have demonstrated significant effectiveness in addressing the knowledge scarcity and hallucination issues of Large Language Models (LLMs). Compared to traditional approaches relying on documents as knowledge sources, Knowledge Graphs (KGs) enable GraphRAG to emerge as a superior solution through their capability to capture complex inter-dependencies. However, existing GraphRAG methods still exhibit limitations: insufficient attention to optimizing KG construction, introduction of excessive irrelevant information during recall optimization in retriever, and inadequate consideration of the generator's data preferences during retrieval refinement. In this paper, we propose a novel framework KD-GAG that efficiently constructs KGs by distilling teacher LLMs' semantics and reasoning into a smaller student LLM. Furthermore, we propose a preference-based subgraph pruning method to optimize the retrieval process. This method automatically learns subgraph pruning strategies through answer quality feedback and aligns the retriever's selection mechanism with the generator's knowledge preferences. Extensive experiments on four QA benchmarks, including HotpotQA, 2WikiMQA, NQ, and MedHop, demonstrate that KD-GAG achieves strong and consistent performance across multi-hop QA, open-domain QA, and biomedical reasoning settings.
Related Concept Videos
Graphical Representation of Inequalities
Graphs of Functions
Deductive Reasoning
Graphs of Two-Variable Functions
Heuristics
People often rely on heuristics when faced with an overload of information, limited time, low importance of the decision, limited information, or when a heuristic readily comes to mind. For...
Graphs of Equations in Two Variables