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Updated: Sep 14, 2026

Culture and Imaging of Ex Vivo Organotypic Pseudomyxoma Peritonei Tumor Slices from Resected Human Tumor Specimens

Culture and Imaging of Ex Vivo Organotypic Pseudomyxoma Peritonei Tumor Slices from Resected Human Tumor Specimens

Published on: December 9, 2022

Synchronous Low-Grade Appendiceal Mucinous Neoplasm and Neuroendocrine Tumor Presenting as Pseudomyxoma Peritonei: A

Tyler Stevens^1,2, Luther Fleury³, Jessica Collera⁴

¹General Surgery, Hospital Corporation of America (HCA) Healthcare/University of South Florida (USF) Health Morsani College of Medicine Graduate Medical Education (GME), Brandon, USA.

|September 13, 2026

Abstract:

Synchronous primary neoplasms of the appendix are exceptionally rare. We report a low-grade appendiceal mucinous neoplasm (LAMN) and a well-differentiated neuroendocrine tumor (NET) arising within the same appendix and presenting as pseudomyxoma peritonei (PMP). A 44-year-old man undergoing staging for a solitary plasmacytoma of the left acetabulum was incidentally found on computed tomography (CT) to have extensive peritoneal mucinosis. Diagnostic laparoscopy confirmed diffuse PMP, and appendectomy revealed two synchronous appendiceal primaries: a perforated LAMN (pT4a pNX) and a 6 mm, grade 1 NET with lymphovascular invasion (pT3 pNX). After multidisciplinary review, the patient completed radiation therapy for the plasmacytoma and subsequently underwent cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (CRS/HIPEC), achieving complete cytoreduction with 33 lymph nodes negative for malignancy. This case highlights the importance of intraoperative suspicion for an appendiceal origin of PMP, the definitive role of histopathology in identifying synchronous pathologies, and the value of coordinated multidisciplinary care when multiple malignancies coexist.

Keywords:

appendiceal neuroendocrine tumor appendix cancer cytoreductive surgery and hipec literature review of disease low-grade mucinous appendiceal neoplasm pseudomyxoma peritonei right colectomy solitary bone plasmacytoma surgical case reports

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