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Updated: Sep 15, 2026

Microwave-assisted Functionalization of Poly(ethylene glycol) and On-resin Peptides for Use in Chain Polymerizations and Hydrogel Formation
Published on: October 29, 2013
Integrated DoE strategy for the development of low-release hydrogels
Catherine Nadeau1, Sofie Dhondt1, Fatma Moawad1,2
1Faculté de Pharmacie, Université de Montréal, 2900 Boul. Édouard-Montpetit, Montréal, Québec, H3T 1J4, Canada. davide.brambilla@umontreal.ca.
Abstract:
A design of experiments approach was used to build a poly(ethylene glycol) diacrylamide (PEGDAAm) hydrogel library and identify the key formulation factors governing protein release. The optimized formulation demonstrated low protein release, and its translational potential was confirmed by loading uricase enzyme, which exhibited low release while maintaining enzymatic activity.
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