Related Experiment Video
Updated: Sep 15, 2026

Genetic Encoding of a Non-Canonical Amino Acid for the Generation of Antibody-Drug Conjugates Through a Fast Bioorthogonal Reaction
Published on: September 14, 2018
Alternating iterative exponential growth oligomers as a sequence-defined platform for hydrophilic antibody-drug
Zihuan Fu1, Heather D Maynard1
1Department of Chemistry and Biochemistry and California NanoSystems Institute, University of California, Los Angeles, Los Angeles, California, 90095-1569, USA. hmaynard@ucla.edu.
Abstract:
Antibody-drug conjugates (ADCs) are a powerful therapeutic modality capable of tissue-specific delivery of highly potent cytotoxic warheads. One of the key challenges of ADCs is their hydrophobicity. Conjugation of typically hydrophobic cytotoxins to an antibody alters its physicochemical properties, resulting in decreased stability and poor pharmacokinetics. Herein, we report the synthesis of alternating iterative exponential growth (IEG) oligomers bearing orthogonal functionalities that serve as a versatile platform for installing diverse hydrophilic moieties and cytotoxic payloads. Incorporation of hydrophilic groups can partially offset payload hydrophobicity, yielding ADCs with improved overall hydrophilicity.
More Related Videos
09:34Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly
Published on: February 6, 2020
10:17Creating Highly Specific Chemically Induced Protein Dimerization Systems by Stepwise Phage Selection of a Combinatorial Single-Domain Antibody Library
Published on: January 14, 2020
Related Concept Videos
Step-Growth Polymerization: Overview
Many natural and synthetic polymers are produced by...
Hybridoma Technology
Hybridoma Selection
Commonly used fusion techniques — electroporation, polyethylene glycol...
Olefin Metathesis Polymerization: Acyclic Diene Metathesis (ADMET)
Similar to cross-metathesis, ADMET also involves the formation of metallacyclobutane intermediate by [2+2] cycloaddition of one of the double bonds of a terminal diene with...