Related Experiment Video

Updated: Sep 15, 2026

Evaluation of a Novel Laser-assisted Coronary Anastomotic Connector - the Trinity Clip - in a Porcine Off-pump Bypass Model

Evaluation of a Novel Laser-assisted Coronary Anastomotic Connector - the Trinity Clip - in a Porcine Off-pump Bypass Model

Published on: November 24, 2014

Minicrush or T-Stenting and Minimal Protrusion in Complex Coronary Bifurcation Lesions: The Multicenter TREX Registry

Giulio Piedimonte¹, Enrico Cerrato¹, Lorenzo Azzalini²

¹Interventional Cardiology Unit, San Luigi Gonzaga University Hospital, Orbassano and Infermi Hospital, Rivoli, (Turin), Italy (G.P., E.C., F.T., C.R., M.P., A.F., G.Z., S.Z., F.V.).

Circulation. Cardiovascular Interventions

|September 14, 2026

Abstract

Background:

Percutaneous coronary intervention of complex coronary bifurcation lesions frequently requires an upfront 2-stent strategy. Although the double kissing crush technique has been extensively studied, limited contemporary data are available comparing alternative 2-stent approaches, particularly Minicrush and T-stenting and minimal protrusion (TAP), in complex bifurcation anatomy. This study aimed to compare procedural characteristics and long-term clinical outcomes of Minicrush versus TAP stenting techniques in patients undergoing percutaneous coronary intervention for complex coronary bifurcation lesions.

Methods:

The TREX registry is a multicenter, retrospective cohort study including consecutive patients treated with an upfront 2-stent strategy using Minicrush or TAP between November 2015 and April 2025. The primary end point was target lesion failure. Secondary end points included major adverse cardiac events and definite or probable stent thrombosis. Clinical outcomes were assessed for up to 10 years.

Results:

Among 601 screened patients, 469 (78%) underwent an upfront 2-stent strategy (Minicrush: n=257; TAP: n=212). TLF occurred in 10.4% of patients, with no significant differences between groups at 1, 5, or 10 years. Major cardiovascular event rates were also comparable across all time points. In multivariable analyses, distal left main involvement and severe coronary calcification were the strongest predictors of TLF, whereas reduced left ventricular ejection fraction was the main predictor of major cardiovascular events. Definite or probable stent thrombosis occurred more frequently with TAP than with Minicrush (5.7% versus 0.8%; P<0.01).

Conclusions:

Minicrush and TAP provide comparable long-term efficacy in complex coronary bifurcation percutaneous coronary intervention; however, Minicrush is associated with a lower risk of stent thrombosis, suggesting a more favorable safety profile.

Registration:

URL: https://clinicaltrials.gov/; Unique Identifier: NCT06484647.

Keywords:

coronary angiography drug-eluting stunts percutenaous coronary intervention stents treatment outcome

Related Concept Videos

Mitral Stenosis III: Medical Management

Mitral Stenosis III: Medical Management

Mitral stenosis, a condition marked by the narrowing of the mitral valve, necessitates an integrated approach for effective management. This approach includes preventative measures, medical therapy, and surgical interventions to reduce symptoms and prevent complications.PreventionPrevention of mitral stenosis primarily focuses on reducing the incidence of bacterial infections, particularly streptococcal infections, which can lead to rheumatic fever and subsequent valvular damage. Timely...

Coronary Artery Disease I: Introduction

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...

Mitral Regurgitation III: Medical Management

Mitral Regurgitation III: Medical Management

Mitral regurgitation (MR) is characterized by retrograde blood circulation from the left ventricle into the left atrium due to inadequate mitral valve closure. The severity of the condition, symptoms, and underlying cause determine treatment strategies.Monitoring and Pharmacological TreatmentPatients with mild to moderate MR typically do not need immediate intervention but regular monitoring to assess progression and guide treatment. Patients with mild MR should have an echocardiogram every 3-5...

Articles linked to this work by shared authors, journal, and citation graph.

Impact of right ventricular to pulmonary artery coupling in patients undergoing catheter ablation of atrial fibrillation.

Journal of cardiovascular medicine (Hagerstown, Md.)·2026

De-escalation of antiplatelet therapy to evaluate platelet reactivity and clinical outcomes after coronary stenting in patients at high bleeding risk and recent acute coronary syndrome: Rationale and design of the DESC-HBR trial.

Cardiovascular revascularization medicine : including molecular interventions·2026

Improved Prognostic Staging in Endometrial Cancer: Clinical Impact of Aggressive Subtypes in a Multicenter Cohort.

Medical sciences (Basel, Switzerland)·2026

Standard clinical and stress electrocardiogram variables to exclude left main and left main-equivalent disease: the MASTER study.

European heart journal·2026

Spontaneous Coronary Artery Dissection, Apical Thrombus and Unknown Hyperthyroidism: A Clinical Case.

Journal of clinical medicine·2026

Suppression of Early TNF-Alpha Increase by a Single Evolocumab Dose in Patients with Acute Myocardial Infarction Undergoing Percutaneous Coronary Intervention.

Journal of clinical medicine·2026

See all related articles