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Bone densitometry using computed tomography. Part II: increased trabecular bone density in children with chronic
The British Journal of Radiology
|January 1, 1979
Summary
Gamma-ray CT bone densitometry reveals increased trabecular bone density (TBD) in most children with chronic renal failure (CRF). This non-invasive method objectively documents osteosclerosis in CRF.
Area of Science:
- Radiology
- Bone Densitometry
- Nephrology
Background:
- Chronic renal failure (CRF) can lead to renal osteodystrophy, often presenting with osteosclerosis.
- Previous bone mineral measurement methods have limitations in detecting changes associated with CRF.
Purpose of the Study:
- To evaluate the utility of gamma-ray computed tomography (gamma-ray CT) bone densitometry in assessing bone changes in children with CRF.
- To objectively document osteosclerosis in CRF using a novel non-invasive technique.
Main Methods:
- Gamma-ray CT bone densitometry was used to measure trabecular bone density (TBD), bone density (BD), and total absorption (TA).
- Nine children with CRF (serum creatinine > 5 mg/100 ml) were studied.
- Radiographic signs of secondary hyperparathyroidism and subjective diagnoses of osteosclerosis were assessed.
Main Results:
- Seven of nine children with CRF exhibited increased TBD values.
- Other bone mineral parameters (BD, TA) were generally normal.
- Increased TBD correlated with radiographic signs of secondary hyperparathyroidism.
- Gamma-ray CT provided objective, non-invasive documentation of osteosclerosis in CRF.
Conclusions:
- Gamma-ray CT bone densitometry is a valuable tool for the selective and objective assessment of bone changes in CRF.
- This method can detect increased TBD and document osteosclerosis, which were missed by previous techniques.
- Gamma-ray CT helps elucidate the pathophysiology of renal osteodystrophy.