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Preparation of Mesenchymal Stromal Cells-Derived Extracellular Vesicles as Carriers for Paclitaxel Delivery

Angela Marcianti1, Catia Traversari1, Daniela Lisini2

  • 1Cell Therapy Production Unit, Scientific Direction, Fondazione IRCCS Istituto Neurologico C. Besta, Milano, 20133, Italy.

Methods in Molecular Biology (Clifton, N.J.)
|September 14, 2026
PubMed

Keywords:
Cell cultureDrug deliveryExtracellular vesiclesGood manufacturing practiceInvestigational medicinal productMesenchymal stromal cells

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Mesenchymal Stem Cells

Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their access...