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Updated: Sep 16, 2026

Morphology-Based Distinction Between Healthy and Pathological Cells Utilizing Fourier Transforms and Self-Organizing Maps
Published on: October 28, 2018
Scherer's map, remapped
Daniel J Silver1, Chang Xu2, Justin D Lathia3
1Department of Cancer Sciences, Cleveland Clinic Research, Cleveland, OH, USA; Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH, USA; Department of Pathology, Cleveland Clinic Lerner College of Medicine, Cleveland, OH, USA.
Abstract:
Scherer's century-old classification of expansive and infiltrative glioma growth remains foundational to neuro-oncology. In this issue of Cancer Cell, Hoefflin et al. use spatial RNA and protein profiling of IDH-mutant gliomas to reveal hypoxia and necrosis as organizing centers of expansive growth and white-matter tracts as guides and constraints on invasion.

