Spontaneous Massive Intrathoracic Hematoma in a Patient with Marfan Syndrome

Although aortic complications are common in patients with Marfan syndrome (MFS), spontaneous peripheral arterial rupture is rare. Herein, we report a 40-year-old woman with MFS who presented with left-sided chest pain and hoarseness due to a massive intrathoracic hematoma. She had undergone multiple thoracic surgeries for aortic dissection. Rupture of fragile neovessels associated with surgery-related inflammation was suspected. Hemostasis was achieved by transcatheter embolization of the left lateral thoracic and supreme intercostal arteries. Intrathoracic bleeding should be considered in patients with MFS presenting with chest pain or hoarseness, particularly those receiving anticoagulation therapy or those who have undergone prior thoracic surgery.