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Inhibition of Aspergillus flavus Growth and Aflatoxin Production in Transgenic Maize Expressing the α-amylase Inhibitor from Lablab purpureus L.
Published on: February 15, 2019
Flavasperfurans A and B, Two New Asperfuran Derivatives From the Marine-Derived Fungus Aspergillus flavus
Chun-Xiu Wang1,2, Zheng-Biao Zou2, Li-Sheng Li3
1Institute of Marine Drugs, Guangxi University of Chinese Medicine, Nanning, China.
Abstract:
Marine microorganisms represent a prolific reservoir of chemically diverse natural products endowed with considerable therapeutic potential. In the present study, two new asperfurans (1 and 2) and 23 known compounds (3-25) were obtained from Aspergillus flavus, a marine fungus isolated from a water sample of the Western Pacific. Their structures were determined by detailed analysis of the 1D and 2D NMR, HRESIMS, and NMR calculations with DP4+ probability analysis, as well as ECD calculations. Asperfuran (3) exhibited potent inhibitory activity against renin-angiotensin system-selective lethal 3 (RSL3)-induced ferroptosis with a half maximal effective concentration (EC50) value of 0.81 µM.
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