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Updated: Sep 17, 2026

Analysis of Human T Cell Activity in an Allogeneic Co-Culture Setting of Pre-Treated Tumor Cells
Published on: March 7, 2025
Chronotherapy with immune checkpoint inhibitors: The knowns, the unknowns, and the contested
Zeynep Melis Gül1, Qun Zeng1, Doron Merkler2
1Department of Pathology and Immunology, Faculty of Medicine, University of Geneva, Geneva, Switzerland.
Abstract:
Emerging data indicate that immune checkpoint inhibitors can exhibit time-of-day-dependent effects in pre-clinical models. Furthermore, multiple retrospective clinical trials associate earlier anti-tumor treatment timing with improved outcomes. However, key questions remain regarding the reproducibility of these findings, the underlying mechanisms, and their clinical implications. This commentary discusses these open questions and provides an outlook on the field.
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