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Updated: Sep 17, 2026

Therapeutic Evaluation of Fecal Microbiota Transplantation in an Interleukin 10-Deficient Mouse Model
Published on: April 6, 2022
Postelectroacupuncture Fecal Microbiota Transplantation (post-EA FMT) Regulates Gastrointestinal Hormones in
Yong-Li Han1, Dong-Fang Shang2, Juli Tang3
1Acupuncture Department, The First Affiliated Hospital of Henan University of CM, Zhengzhou, Henan Province, China.
Background:
Electroacupuncture (EA) reshapes intestinal flora; whether post-EA fecal microbiota transplantation (post-EA FMT) regulates gastrointestinal hormones via the gut microbiota-bile acid (BA) pathway remains unclear.
Methods:
Sham EA (SEA) served as control. Gastrointestinal hormones/motility were assessed post-EA. Fecal microbiota from EA/SEA-treated rats were transplanted into pseudo-germ-free (PGF) rats. Gut microbiota and BA profiles were analyzed.
Results:
EA downregulated Ghrelin, PYY, GLP-1, upregulated CCK, and enhanced motility in FD rats. Post-EA FMT increased Firmicutes/Bacteroidetes (phylum); upregulated Lactobacillus, Prevotella, [Prevotella] (genus); decreased Blautia, Proteobacteria, Bacteroides; reduced multiple BAs (including TUDCA/TCDCA). TUDCA/TCDCA showed strong positive correlation.
Conclusions:
The gut microbiota-BA pathway associates with post-EA FMT's beneficial regulation of gastrointestinal hormones. The gut microbiota-BA pathway is associated with post-EA FMT's beneficial regulation of gastrointestinal hormones. The gut microbiota-BA pathway is associated with post-EA FMT's beneficial regulation of gastrointestinal hormones. The Lactobacillus/TUDCA/TCDCA axis represents a candidate pathway that may contribute to this process (validation pending). Current findings indicate strong correlations, not causality.
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