Related Experiment Video
Updated: Sep 17, 2026

Regenerative Peripheral Nerve Interface: Surgical Protocol for a Randomized Controlled Trial in Postamputation Pain
Published on: March 15, 2024
Amputation for Complex Regional Pain Syndrome Type 1
Kimberley Teo1, Siang Naik1, Kathy Stiller2
1Central Adelaide Local Health Network, The Queen Elizabeth Hospital, Woodville, Australia.
Background:
Complex regional pain syndrome (CRPS) is a chronic condition involving severe pain that can be resistant to many treatment modalities. Therapeutic amputation of the affected limb is unusual and controversial.
Case Report:
A 33-year-old female with a 4-year history of CRPS associated with intractable foot and calf pain underwent elective transtibial amputation after conservative treatments failed. The patient's outcomes were favorable: resolution of pain and improved mobility sustained at 18 months postoperatively.
Conclusion:
Amputation may be a viable last resort treatment option for selected patients with CRPS who are unresponsive to conventional treatments.

