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A Unified Visualization Platform for Longitudinal Macular Structure-Function Assessment in Glaucoma
Vahid Mohammadzadeh1, Benjamin Winjum2, Kouros Nouri-Mahdavi1
1Glaucoma Division, Stein Eye Institute, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California.
Precis:
A cross-device visualization platform, currently assessed on Spectralis and Cirrus OCT systems, integrates macular OCT and central 10-2 visual field data for aligned cross-sectional and longitudinal structure-function assessment.
Purpose:
To develop a unified visualization platform integrating macular optical coherence tomography (OCT) with central 10-2 visual field (VF) data across different OCT devices, enabling concurrent cross-sectional and longitudinal assessment of structure-function relationships in glaucoma.
Methods:
We analyzed 116 eyes from 116 glaucoma patients enrolled in the Advanced Glaucoma Progression Study (AGPS), who underwent serial macular imaging with Spectralis SD-OCT and Cirrus HD-OCT, along with 10-2 perimetry every six months. Raw macular thickness data were exported, interpolated to uniform grids, and aligned to the fovea using rotation and displacement correction. Thickness maps were co-localized with VF test locations using device-specific scaling. The platform enabled interactive selection of retinal layers, spatial resolution, visit intervals, opacity blending, and temporal difference mapping relative to baseline. Structural and functional changes were qualitatively evaluated in progressing and stable eyes.
Results:
The platform successfully harmonized data across OCT devices, allowing anatomically consistent overlay of thickness maps and VF points. In progressing eyes, regions of inner macular layer thinning, including GCC or GCIPL depending on the device/layer selected corresponded to localized VF sensitivity loss, while stable eyes showed minimal changes. Difference mapping and adjustable spatial resolution improved detection of subtle progression, particularly in moderate disease.
Conclusions:
This unified visualization platform enables longitudinal integration of macular OCT and central 10-2 visual field data for assessment of structure-function relationships in glaucoma. The framework may support future quantitative evaluation of glaucoma progression and predictive modeling.