Related Experiment Video
Updated: Sep 17, 2026

Lateral Root Inducible System in Arabidopsis and Maize
Published on: January 14, 2016
Design, synthesis, and structure-activity relationships of ω-aryloxy-α-hydroxyalkanoates as selective lateral root
Takeshi Yamada1, Rie Kikuchi2, Ryuta Hanaoi2
1Faculty of Pharmaceutical Sciences, Kobe Pharmaceutical University, Kobe 658-8558, Japan.
Abstract:
We synthesized a series of ω-aryloxy-α-hydroxyalkanoates and evaluated their effects on Arabidopsis thaliana root architecture. We found that compounds with an odd number of methylene linkers (such as JAX-64) exhibited highly potent overall inhibitory activity for primary root growth and lateral root formation. Structural tuning-such as introducing an ortho-methoxy group or converting the ester to an amide-effectively attenuated the severe primary root inhibition while maintaining sufficient lateral root suppression, yielding highly selective inhibitors. It may be considered that these optimized molecules function in their intact forms. Co-treatment assays with the in vivo indole-3-butyric acid (IBA) generator JAX-44 showed a rightward shift in the lateral root inhibition curve. This suggests that these selective inhibitors putatively target the peroxisomal β-oxidation pathway, which converts IBA to IAA, providing valuable tools for auxin research.
Related Concept Videos
ortho–para-Directing Activators: –CH3, –OH, –⁠NH2, –OCH3
Production of Organic Acids
Local Anesthetics: Chemistry and Structure-Activity Relationship
Regioselectivity and Stereochemistry of Acid-Catalyzed Hydration
Protecting Groups for Aldehydes and Ketones: Introduction
Acetals and Thioacetals as Protecting Groups for Aldehydes and Ketones
In the presence of multiple functional groups, when selective reduction of one group over the other is desired, groups like aldehydes and ketones that form acetals...
