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Collateral sensitivity-harnessing microbial vulnerabilities as a solution to antimicrobial resistance
Rishav Jana1, Priyanka Bhowmik2
1Department of Biological Sciences, School of Life Science & Biotechnology, Adamas University, Barasat - Barrackpore Road, P.O. - Jagannathpur, District - 24 Parganas (North), Kolkata - 700 126, Adamas Knowledge City, West Bengal, India.
Abstract:
Bacteria exhibit an evolutionary trade-off through their development of collateral sensitivity (CS) which allows them to resist one antibiotic while becoming more vulnerable to another. This vulnerability offers a compelling therapeutic opportunity by selecting against resistant isolates. Laboratory evolution studies, genome sequencing, deep mutagenesis and use of artificial intelligence and machine learning can design the bespoke strategy against multi-drug-resistant bacteria. This review discusses about recent studies that are rationally designed to harness this evolutionary trade-off for the development of alternative antimicrobial strategies. The translational barriers to the clinical implementation of CS are addressed and evidence-based design principles for optimization of CS-guided therapy are discussed.
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