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Updated: Sep 18, 2026
An Orthotopic Mouse Model of Anaplastic Thyroid Carcinoma
Published on: April 17, 2013
Sortilin Immunoreactivity Is Associated with Lymphatic and Extrathyroidal Invasion in Medullary Thyroid Carcinoma: A
Emre Gezer1, Seda Duman Öztürk2, Aslı Bala Öcal3
1Faculty of Medicine, Department of Endocrinology and Metabolism, Kocaeli University, Kocaeli, Türkiye.
Introduction:
Medullary thyroid carcinoma (MTC) is a rare aggressive thyroid malignancy lacking reliable molecular markers. Sortilin is associated with tumor invasiveness in several cancers, but its role in MTC remains unclear.
Methods:
Sortilin immunoreactivity was retrospectively evaluated by immunohistochemistry using both staining percentage and H-score in tumor samples from 24 patients who underwent total thyroidectomy for MTC.
Results:
All tumors showed sortilin positivity. Higher staining percentage was significantly associated with lymphatic invasion (p = 0.002) and extrathyroidal extension (p = 0.024), whereas the corresponding H-score comparisons did not reach statistical significance (p = 0.106 and p = 0.160, respectively).
Discussion:
In this preliminary single-center cohort, sortilin staining percentage, but not H-score, was associated with locally invasive histological features. These findings are hypothesis-generating and do not establish sortilin as an independent prognostic biomarker.