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Updated: Sep 18, 2026

Biochemical Measurement of Neonatal Hypoxia
Published on: August 24, 2011
Gas Phase Studies of Purine Base Analogs: Intrinsic Properties and Hypoxanthine-Guanine-(Xanthine)
Xiao Ding1, Lanxin Zhang1, G S M Kiruba1
1Department of Chemistry and Chemical Biology Rutgers, The State University of New Jersey, New Brunswick, New Jersey08901, United States.
Abstract:
The gas-phase acidity and proton affinity of purine nucleobases that are found to be inactive for the enzyme Plasmodium falciparum hypoxanthine-guanine-(xanthine) phosphoribosyltransferase (Pf HG(X)PRT) have been examined using both computational and experimental methods. These thermochemical values have not heretofore been measured and provide experimental data to benchmark the theoretical results. Pf HG(X)PRT is an antimalarial target; our gas-phase results lend insight into the Pf HG(X)PRT mechanism, providing a potential means of predicting enzyme substrate activity.
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