Related Experiment Video

Updated: Sep 18, 2026

Hyperinsulinemic-euglycemic Clamps in Conscious, Unrestrained Mice
11:10

Hyperinsulinemic-euglycemic Clamps in Conscious, Unrestrained Mice

Published on: November 16, 2011

Deoxycalyxin A exerts hypoglycemic effects through activating TGR5-induced GLP-1 secretion via TGR5/PKA/MEK/ERK

Sheng-Li Wu1, Xiao-Feng He2, Pianchou Gongpan2

  • 1State Key Laboratory of Phytochemistry and Natural Medicines, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China; University of Chinese Academy of Sciences, Beijing 100049, China.

Bioorganic Chemistry
|September 16, 2026
PubMed

Keywords:
Deoxycalyxin A (DCA)GLP-1 secretionHypoglycemic effectPKA/MEK/ERK pathwayTGR5 agonistType 2 diabetes mellitus

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