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Targeting Outer Membrane Vesicles of Pseudomonas aeruginosa: From Pathogenesis to Therapeutics
Shuaiyuan Liang1, Nan Gao2, Fan Fei1
1Department of Respiratory and Critical Care Medicine, The Affiliated Jiangning Hospital with Nanjing Medical University, Nanjing 211100, P. R. China.
Abstract:
Multidrug-resistant Pseudomonas aeruginosa (P. aeruginosa) causes a variety of illnesses and has become a major challenge in clinical settings. Outer membrane vesicles (OMVs) have attracted extensive research interest in recent years and are considered a promising platform for managing P. aeruginosa infections. Therefore, it is essential to comprehend the complex mechanisms and possible targets that underlie the interactions between pathogens and OMVs. In this review, we summarize the key components of P. aeruginosa OMVs (PA-OMVs), elucidate their pathogenicity mechanisms, and discuss their potential therapeutic targets. Finally, we provide an overview of recent advances in PA-OMV research.
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