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Published on: January 30, 2017
Recombinant Influenza Vaccine and Influenza Outbreaks in US Nursing Homes: Results From a Pragmatic
Kevin W McConeghy1,2, H Edward Davidson3, Lisa Han3
1Transformative Health Systems Research to Improve Veteran Equity and Independence Center of Innovation (THRIVE COIN), Veterans Affairs Providence Health Care System, Providence, Rhode Island, USA.
Background:
Influenza outbreaks in US nursing homes contribute substantially to morbidity, mortality, and operational strain. Recombinant influenza vaccine may reduce transmission in long-term care settings, but high-quality evidence to support this effect is limited. The purpose of this study was to compare the risk of influenza outbreaks (influenza confirmed: 1 or more laboratory-confirmed cases; influenza suspected: 2 or more influenza-like illness cases) among nursing homes randomized to recombinant quadrivalent influenza vaccine (RIV4) vs standard-dose egg-based inactivated quadrivalent influenza vaccine (IIV4).
Methods:
This study was a pragmatic, cluster-randomized clinical trial conducted across 2 influenza seasons (n = 965 facilities in 2019-2020 and n = 1023 in 2020-2021) in Medicare-certified US nursing homes. Nursing homes with ≥50 long-stay residents and high proportions of adults aged ≥65 years were eligible and assigned to RIV4 or IIV4 for resident and staff vaccination. The outcome was facility-reported influenza outbreaks, assessed by monthly logs.
Results:
During the 2019-2020 season, RIV4-assigned facilities experienced fewer suspected (148 [30.6%] vs 178 [37.0%]) and laboratory-confirmed (177 [36.6%] vs 214 [44.5%]) influenza outbreaks than IIV4 facilities. The adjusted relative risk (RR) for confirmed outbreaks was 0.82 (95% CI, 0.71-0.96). In 2020-2021, confirmed outbreaks were rare (16 vs 15), and no significant differences were observed. Coronavirus disease 2019 outbreak risk did not differ between groups in either season.
Conclusions:
RIV4 reduced influenza outbreak occurrence in US nursing homes during a season with moderate influenza activity in older adults. No differences were observed during the low-circulation 2020-2021 season. These findings suggest that recombinant influenza vaccines may provide clinically meaningful facility-level benefits in long-term care settings during seasons with substantial influenza circulation.
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