Related Experiment Video
Updated: Sep 19, 2026

A Rat Tibial Growth Plate Injury Model to Characterize Repair Mechanisms and Evaluate Growth Plate Regeneration Strategies
Published on: July 4, 2017
[Growth plate regulation and short stature: mechanistic insights and therapeutic advances]
Guo-Sheng Mo1, Yun-Ting Ma1, Bao-Heng Gui1
1Second Clinical School of Guangxi Medical University, Nanning 530007, China.
Abstract:
The growth plate is the key structure for longitudinal growth of long bones, and its function is coordinated by a complex network of systemic endocrine signals, local paracrine signals, structural support from the extracellular matrix, and intracellular signaling pathways. Dysregulation of this network can lead to short stature (SS). At present, treatment of SS mainly relies on various hormone replacement therapies, but efficacy varies. Emerging approaches, including targeted drugs, molecularly targeted delivery, and gene therapy, have demonstrated potential for clinical application. This review describes the structure and function of the growth plate, summarizes the association between its dysfunction and SS, and outlines related research and therapeutic advances, with the aim of informing studies on the molecular pathogenesis of SS and the exploration of precision treatment strategies.
Related Concept Videos
Nature and Nurture
Hormones and Bone Tissue
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
mTOR Signaling and Cancer Progression
The mTOR pathway or the...
Pharmacogenomics: Identification of New Drug Targets
Negative Regulator Molecules
Cells Coordinate Growth and Proliferation

