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Cardiovascular Outcomes With Sodium-Glucose Cotransporter 2 Inhibitors in Ethnically Diverse Patients With Heart
Sun Yong Lee1, Tiffany Vu2, Jessica Song3
1St Joseph's Medical Center, Cardiovascular Disease Fellowship, Department of Medicine/Division of Cardiology, Stockton, California, USA; San Joaquin General Hospital, Internal Medicine Department, French Camp, California, USA. Electronic address: https://twitter.com/SunYongLeeMD1.
Background:
Sodium-glucose cotransporter 2 inhibitors (SGLT2is) have been shown to decrease heart failure hospitalizations (HFHs) and cardiovascular (CV) death; however, Hispanic/Latino patients and methamphetamine (MA) users have been under-represented.
Project Rationale:
The purpose of this retrospective study was to assess CV outcomes in the Central Valley region of California within 12 months of starting a SGLT2i.
Project Summary:
Overall, 413 patients were included, with non-White patients and MA users accounting for 72% and 27% of the population, respectively. The composite CV outcome occurred in 86 of 413 patients (20.8%), 22% of Whites and 19%-27% of non-Whites. Significantly reduced HFH rates were observed in the overall population and subgroups after 1 year of starting SGLT2i. Reduced left ventricular ejection fraction, prior HFH, and MA use predicted CV outcomes, though the retrospective nature of this analysis limits causal inference.
Take-Home Message:
MA use, prior HFH, and reduced left ventricular ejection fraction predicted CV outcomes, irrespective of ethnicity.
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Facilitated diffusion-glucose transporters (GLUTs) are encoded by the solute-linked carrier (SLC) family 2, subfamily A gene family, or SLC2A. The 14 GLUT protein members are distributed into three classes:
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