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Updated: Sep 19, 2026

Measuring Oral Fatty Acid Thresholds, Fat Perception, Fatty Food Liking, and Papillae Density in Humans
Published on: June 4, 2014
From molecular binding to mouthfeel: Oil saturation controls oral lubrication through interfacial protein films
Ruoning Zhang1, Jingyi Xu2, Lei Dai3
1Key Laboratory of Healthy Beverages, China National Light Industry, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing, China; Department of Food Science, Cornell University, Ithaca, NY, USA.
Abstract:
The oily mouthfeel is a critical sensory governed by the lubrication of saliva emulsions during oral processing, but the molecular mechanisms remain unclear. This study investigated this mechanism by using a saturated oil (Medium-chain triglyceride, MCT), a monounsaturated corn oil (CO), and a polyunsaturated linseed oil (LO). LO (polyunsaturated) exhibited high-energy binding to salivary mucin, inducing significant protein denaturation. These unfolded proteins formed deficient interfacial films with low viscoelasticity, causing rapid coalescence and lubrication failure. Conversely, MCT (saturated) showed moderate binding that preserved mucin structure, enabling the formation of elastic interfacial films. These stable emulsions provided effective lubrication via a ball-bearing mechanism. This structure-function relationship demonstrated that oil composition regulated oral lubrication by tuning conformation of salivary protein at the interface, which offered a molecular basis for oiliness design.
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