How to grow a filament: Lessons from the RAD51 paralogs toolbox

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Real-time Observation of the DNA Strand Exchange Reaction Mediated by Rad51
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Luca Pellegrini1

  • 1Department of Biochemistry, University of Cambridge, Cambridge CB2 1GA, UK.

Molecular Cell
|September 17, 2026
PubMed

Abstract:

In this issue of Molecular Cell, Koo et al.1 describe how the yeast Rad55-Rad57-SHU complex dynamically nucleates Rad51 filaments on DNA. Functional coupling between Rad55-Rad57 and Rad51 on ssDNA seeds filament growth, whilst ATP hydrolysis promotes complex turnover.

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