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Updated: Sep 19, 2026

Development of Compendium for Esophageal Squamous Cell Carcinoma
Published on: April 12, 2024
NCCN Guidelines® Insights: Esophageal and Esophagogastric Junction Cancers, Version 4.2026
Jaffer A Ajani1, Thomas A D'Amico2, David J Bentrem3
11The University of Texas MD Anderson Cancer Center.
Abstract:
Esophageal cancer is the seventh leading cause of cancer-related deaths worldwide. Esophageal cancers are histologically classified as squamous cell carcinoma (ESCC) or adenocarcinoma (EAC), which differ in their etiology, pathology, tumor location, therapeutics, and prognosis. In patients with locally advanced or metastatic disease, systemic therapy can provide palliation, improve survival, and/or enhance quality of life. The implementation of biomarker testing and immunotherapy has had a significant impact on clinical practice and patient care. This selection from the NCCN Guidelines for Esophageal and Esophagogastric Junction Cancers highlights current recommendations for advanced ESCC, including the evolving landscape of first-line immunotherapy.
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