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Updated: Sep 19, 2026

Identification of Key Factors Regulating Self-renewal and Differentiation in EML Hematopoietic Precursor Cells by RNA-sequencing Analysis
Published on: November 11, 2014
Cell fate decision and lineage specification mechanisms in hematopoiesis
In-Won Lee1, Yesenia Earth1, Yoon-A Kang1
1Division of Hematology, Department of Medicine, School of Medicine, Washington University in St. Louis, St. Louis, MO, United States.
Abstract:
Red blood cells constitute over 99 % of all blood cells and 2-3 million erythrocytes are generated every second in human body. The process of generating red blood cells, erythropoiesis, is tightly regulated at the multiple levels of the hematopoietic hierarchy to fulfil this intensive demand for oxygen carrying cells. Recent studies uncovered that lineage specification begins at the multipotent stages such as hematopoietic stem cell (HSC) and multipotent progenitor (MPP) populations. In this review, we discuss lineage-biased HSCs and MPPs, the erythroid linage bias in HSCs and MPPs, how erythroid fate decisions are made in common myeloid progenitors (CMPs) and megakaryocyte-erythroid progenitors (MEPs), and what alters erythroid lineage commitment in aging and disease conditions.
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