Mobile application-based interventions for subjective memory decline and mild cognitive impairment: A systematic...

BackgroundSubjective cognitive decline (SCD) and mild cognitive impairment (MCI) are early clinical markers along the continuum from normal aging to dementia. Both conditions are associated with an elevated risk of progression to Alzheimer's disease and related dementias. With SCD affecting up to 25% and MCI up to 25.2% of older adults, there is growing interest in non-pharmacological, multidomain interventions to address modifiable risk factors, reduce progression, and enhance quality of life. Mobile application-based interventions offer a promising avenue for older populations due to their convenience, reduced need for travel, and personalized engagement.ObjectiveThis systematic review aimed to evaluate the effectiveness of mobile application-based interventions on cognitive performance in individuals with SCD and/or MCI.MethodsA systematic review of randomized controlled trials was conducted to identify mobile application-based interventions targeting SCD and MCI from 2010 to 2025. We conducted a comprehensive search in PubMed, Web of Science, and Scopus databases following PRISMA guidelines.ResultsA total of 3140 abstracts were screened, of which 19 (0.6%) met the inclusion criteria. Seven studies focused on SCD, while the majority targeted patients with MCI. All but one study reported improvements in at least one cognitive outcome following the intervention.ConclusionsMobile application-based interventions show promising benefits for individuals with SCD and MCI, with most studies reporting improvements in cognitive outcomes, particularly in memory. However, further research with larger samples and more extended follow-up periods is needed to confirm these findings and optimize intervention strategies.