A Magneto-Electric Synergistic Bioelectronic Suture for Antibacterial Therapy, Wireless Electrical Stimulation, and...

Electroactive sutures show great potential for surgical wound management but remain limited by wired power supplies, unreliable biomechanical energy harvesting, and inadequate antibacterial performance. Here, we develop an electromagnetic induction-enabled electroactive antibacterial suture (SDTP) via hierarchical polydopamine-mediated assembly of tannic acid (TA) and polypyrrole (PPy). TA functions as both a broad-spectrum antibacterial agent and a dopant to form a dense conductive PPy network. Under a rotating magnetic field (RMF), the implanted suture wirelessly generates controllable microcurrents ranging from 1.0 to 4.8 µA. The RMF-triggered electrical stimulation synergizes with TA to achieve antibacterial rates exceeding 99% against Staphylococcus aureus and 96% against Escherichia coli. In an acute infected wound model, SDTP combined with RMF significantly accelerates healing, promoting inflammation resolution, angiogenesis, and collagen deposition. This therapeutic effect is attributed to the synergistic effects of TA-mediated antibacterial activity, the inherent bioeffects of RMF, and SDTP-generated electrical stimulation under RMF activation. Moreover, the conductive PPy network endows the suture with piezoresistive strain-sensing capability, enabling real-time monitoring of biomechanical motion and demonstrating potential for early warning of wound dehiscence. This work presents a wireless magneto-electric suture platform that integrates antibacterial therapy, regenerative modulation, and biomechanical sensing for intelligent wound management.