Related Experiment Video
Updated: Sep 19, 2026

Development of Obliterative Bronchiolitis in a Murine Model of Orthotopic Lung Transplantation
Published on: July 10, 2012
Bronchiectasis in immunodeficiency
Jordon L Jaggers1, James M Fernandez
1Department of Allergy and Clinical Immunology, Cleveland Clinic, Cleveland, Ohio, USA.
Purpose Of Review:
As the field of bronchiectasis continues to advance, so does the recognition of undiagnosed immunodeficiency as a potential contributor. This review aims to highlight what is currently known about bronchiectasis in immunodeficiency as well as explore future therapeutics and needs.
Recent Findings:
Guidelines emphasize the need for evaluation for underlying immunodeficiency in patients with known bronchiectasis. Despite this known association, evaluation continues to be variable in clinical practice resulting in potentially missed therapeutic options, such as immunoglobulin replacement therapy in the setting of immunodeficiency. While the mainstay treatment for those with bronchiectasis and immunodeficiency continues to be immunoglobulin replacement therapy and prophylactic antibiotics, the future is hopeful with more directed therapy for the underlying pathophysiology of bronchiectasis with targeted agents such as brensocatib.
Summary:
This review highlights the need for ongoing research to improve detection of bronchiectasis in immunodeficiency and include patients with immunodeficiency and bronchiectasis in trial designs for therapeutics in bronchiectasis.
Related Concept Videos
Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features
Immunodeficiency Diseases
There are three main causes of immunodeficiency disorders...
Pulmonary Tuberculosis I
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Chronic Obstructive Pulmonary Disease II: Emphysema
Chronic Obstructive Pulmonary Disease-II: Pathophysiology
Chronic Inflammation
Pulmonary Tuberculosis II
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...