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Updated: Sep 19, 2026

Granulocyte-dependent Autoantibody-induced Skin Blistering
Published on: October 12, 2012
Case Report: A case of cutaneous collagenous vasculopathy
Chenjian Tang1, Liping Chen2, Jiangxiu Yu3
1Department of Acupuncture, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Abstract:
We report a case of a 62-year-old woman presenting with a 6-year history of purpuric patches and macules on the lower extremities, initially misdiagnosed as allergic purpura and treated with prednisone. Skin biopsy revealed dilated dermal vessels with perivascular collagen deposition, positive for collagen IV and diastase-periodic acid-Schiff (D-PAS) staining, consistent with cutaneous collagenous vasculopathy (CCV). Treatment included hydroxychloroquine, vitamin C, doxepin, and topical mucopolysaccharide polysulfate cream. Prednisone was tapered by one tablet every 3 days. After 4 weeks, the rash improved significantly with no new lesions. We would like to present a case of CCV.
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