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Total synthesis of kasichelins A and B
Yu-Qin Tang1, Xue-Hua Huang1, Xin-Yi Tong1
1School of Pharmacy and Food Engineering, Wuyi University, Jiangmen, Guangdong, 529020, China. yanjialei@wyu.edu.cn.
Abstract:
The first total synthesis of kasichelins A and B was accomplished in a concise manner via a longest linear sequence of seven steps with 25% and 18% overall yields, respectively. The synthetic route featured a judicious choice of protecting groups, a molybdenum-promoted dehydrative cyclization for construction of the dihydrooxazole core, and a convergent fragment assembly strategy to forge the complete molecular scaffold.
