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Shape-constrained semiparametric maximum likelihood for backward time under an accelerated failure time model
1Office of Biostatistics Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 5601 Fishers Lane, Rockville, MD, 20892, USA. jingqin@niaid.nih.gov.
Abstract:
We investigate semiparametric maximum likelihood inference for backward (current-duration, backward-recurrence) times arising in cross-sectional (prevalent-cohort) sampling under an accelerated failure time (AFT) model for the underlying forward lifetime. A key observation is that, after a suitable transformation, the baseline density of backward times is intrinsically monotone non-increasing. Exploiting this shape constraint yields a profile likelihood estimator for the regression parameter β together with a nonparametric maximum likelihood estimator (NPMLE) of the monotone density via the Grenander estimator. Because the Grenander estimator is known to behave poorly near the origin-often causing instability in AFT parameter estimation-we additionally consider a log-concavity constraint on the backward density, which leads to substantially more stable estimation in practice. We present a rigorous formulation of the likelihood, provide sufficient conditions for identifiability, and establish consistency of the profile MLE. We further highlight the importance of restricting the parameter space for β to a compact set: this is essential for both identifiability and numerical stability, as the likelihood may otherwise be flat or ill-behaved. Finally, we propose a practical multi-start estimation procedure that integrates shape-restricted projection of the nonparametric component with derivative-free optimization of the parametric component.
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