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The dorsal bundle extinction effect:dependence on subtle changes in acquisition.

S T Mason, H C Fibiger

    Brain Research
    |April 27, 1979
    PubMed
    Summary
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    Noradrenergic system damage in rats impairs extinction learning only if it occurs during initial training. This suggests the noradrenergic system influences how animals acquire new behaviors, impacting future learning.

    Area of Science:

    • Neuroscience
    • Behavioral Neuroscience
    • Neuropharmacology

    Background:

    • The ascending noradrenergic system plays a crucial role in cognitive functions, including learning and memory.
    • Previous research suggests noradrenergic pathways are involved in extinction learning, but the precise timing of their involvement remains unclear.

    Purpose of the Study:

    • To investigate the role of the ascending noradrenergic innervation to the forebrain in extinction of a learned response in rats.
    • To determine if the timing of noradrenergic system disruption (during acquisition vs. extinction) affects behavioral outcomes.

    Main Methods:

    • Selective neurotoxin 6-hydroxydopamine was used to lesion the ascending noradrenergic innervation to the forebrain in rats.
    • Lesions were inflicted bilaterally into the dorsal bundle in the mesencephalon.

    Related Experiment Videos

  • Rats underwent acquisition training on a continuously reinforced lever press schedule, with lesions occurring either during acquisition or prior to extinction.

    • Main Results:

    • Destruction of noradrenergic innervation to the forebrain resulted in resistance to extinction of a continuously reinforced lever press response.
    • This resistance to extinction was observed only when the lesion was present during acquisition training.
    • Lesioning animals after acquisition training, but before extinction, did not produce the same effect.

    Conclusions:

    • The behavioral effect observed during extinction is likely due to subtle alterations in the acquisition learning process caused by noradrenergic system damage.
    • These findings support an attentional theory of noradrenergic function.
    • The results exclude alternative explanations for the dorsal bundle extinction effect.