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Updated: Sep 20, 2026

T Cells Capture Bacteria by Transinfection from Dendritic Cells
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γδ T cells BiTE back at small cell lung cancer
David A Hamilton1, Mohindar M Karunakaran2, Seth B Coffelt1
1School of Cancer Sciences, College of Medical, Veterinary & Life Sciences, University of Glasgow, Glasgow, UK; Cancer Research UK Scotland Institute, Glasgow, UK.
Abstract:
In this issue of Cancer Cell, Ng et al. characterize and leverage cytotoxic γδ T cells in small cell lung cancer to overcome unsuccessful checkpoint blockade immunotherapy. Engaging Vδ2+ cells with a bispecific T cell engager (BiTE) bypasses the challenge of low MHC-I expression and ineffective CD8+ T cells.
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