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Ameloblastoma With Glandular Differentiation
Melad N Dababneh1, Michel Kmeid1, Alexander C Mackinnon1
1Department of Pathology, Heersink School of Medicine, The University of Alabama at Birmingham, Birmingham, AL, USA.
Abstract:
Ameloblastoma with mucinous and/or glandular differentiation is exceedingly rare and not currently recognized by the World Health Organization (WHO) as a morphologic subtype. We report a KRASG12R-mutated mandibular ameloblastoma with mucinous glandular differentiation in a 72-year-old male patient, with detailed radiologic, histomorphologic, immunohistochemical and molecular findings. To our knowledge, this is the 15th case report in literature of human ameloblastoma with a mucinous component, and the first to provide comprehensive analysis to support glandular differentiation.
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