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Updated: Sep 21, 2026

Mouse Model of Metabolic Dysfunction-Associated Steatotic Liver Disease with Fibrosis
Published on: July 18, 2025
Metabolic Dysfunction-Associated Steatohepatitis: Is there evidence for fractured CD4+ T cell tolerance in the
Abigail E Russi1, Brian J DeBosch2
1Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, USA; Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN, USA; Nutrition & Molecular Metabolism Center, Indiana University School of Medicine, Indianapolis, IN, USA.
Abstract:
Metabolic dysfunction-associated liver disease (MASLD) is defined by hepatic steatosis with concomitant metabolic risk factors and is the leading cause of chronic liver disease. In approximately one-third of individuals, the disease progresses to metabolic dysfunction-associated steatohepatitis (MASH), a more severe form encompassing steatosis with inflammation and hepatocellular injury predisposing to liver failure, cirrhosis, and hepatocellular carcinoma. The mechanism(s) responsible for this aberrant inflammation are unknown. In this review, we explore the breakdown of the hepatic tolerogenic environment in MASH with discussion on fractured CD4+ T cell tolerance as an integral driver of the progression of MASLD to MASH.
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