The Assessment of T-Lymphocytes In Gastric Adenocarcinomas

Gastric adenocarcinomas (GAC) are common cancers in pathology, which pose real problems in practice due to heterogeneity, response to treatment and prognosis. New therapeutic approaches in GAC are aimed at activating the immune system by unblocking or modulating it. In this study, we analyzed the density and distribution of intra- and peritumoral CD4 and CD8 lymphocytes, by immunohistochemistry, in relation to the main prognostic parameters of GAC. CD4 and CD8 lymphocytes were superior in the tumor compartments in the case of discohesive and mixed GAC. They also predominated in discohesive GAC with signet ring cells at the intratumoral level and in those without other specifications at the peritumoral level. CD4 and CD8 were superior in high-grade GAC, in stages II/III and with lymphovascular invasion, more frequently peritumoral. The study indicated differences in the distribution of CD4 and CD8 T lymphocytes that may be useful for improving patient stratification for personalized targeted therapy of GAC.