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Updated: Sep 22, 2026

An Intestine/Liver Microphysiological System for Drug Pharmacokinetic and Toxicological Assessment
Published on: December 3, 2020
Cross-Species Translation of Drug-Induced Toxicity in the Small Intestine Using Mathematical Modeling
1Centre for Systems Modelling & Quantitative Biomedicine (SMQB), University of Birmingham, Birmingham, UK. l.gall@bham.ac.uk.
Abstract:
We previously detailed a quantitative systems toxicology modeling framework for early prediction of chemotherapeutic-induced clinical intestinal adverse effects. The model describes stem and progenitor cell dynamics in the small intestinal epithelium and integrates epithelial-related processes, such as transcriptional profiles, citrulline kinetics, and the probability that the organism will have diarrhea. This protocol describes a step-by-step guide to the examples detailed in the original manuscript, namely 5-FU- and doxorubicin-induced intestinal toxicity.
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