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Updated: Sep 22, 2026

Myeloid Innate Signaling Pathway Regulation by MALT1 Paracaspase Activity
Published on: January 7, 2019
Metrnl in mitigating radiation enteritis via label-retaining cells protection by modulating the c-KIT-WNT pathway
Sailong Zhang1, Simin Chen1, Bingjie Guo2
1Department of Pharmacology, Second Military Medical University/Naval Medical University, Shanghai 200433, China.
Abstract:
Currently, there exists no definitive standardized therapy for radiation enteritis. This study unveils Metrnl as a pivotal regulator of intestinal radioprotection through multi-dimensional single-cell profiling and mechanistic dissection. We first demonstrate that radiation dynamically reprograms Metrnl expression in a time-dependent manner, revealing its role as a radiation-responsive mediator. Crucially, Metrnl confers potent protection against radiation-induced intestinal injury through double mechanisms; Metrnl safeguards label-retaining cells (LRCs) rather than conventional Lgr5+ intestinal stem cells, and activates a novel c-KIT-WNT signaling axis via ERK/GSK3β-mediated pathway crosstalk, both revitalizing intestinal epithelial regeneration. Therapeutically, recombinant Metrnl emerges as a potential biotherapeutic, effectively attenuating radiation enteritis. These findings establish Metrnl as a key mediator bridging radiation biology and regenerative medicine, offering a transformative potential for radiation injury management.
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