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Photobiomodulation Irradiation Protocols for Burning Mouth Syndrome: A Systematic Review and Protocol-Level
Soo-Min Ok1,2, Misoon Lee3
1Department of Oral Medicine, Dental and Life Science Institute, School of Dentistry, Pusan National University, Yangsan-si, Republic of Korea.
Objectives:
To evaluate the effects of photobiomodulation therapy/low-level laser therapy (PBMT/LLLT) on burning mouth syndrome (BMS) and to explore whether irradiation protocol variables modify treatment effects.
Methods:
Randomized controlled trials were synthesized according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) and Cochrane guidance. The protocol was registered in International Prospective Register of Systematic Reviews (PROSPERO) (CRD420261329136). Random-effects meta-analyses evaluated pain, Oral Health Impact Profile-14 (OHIP-14), xerostomia, anxiety, and depression. Irradiation-related subgroup analyses, including wavelength, power, fluence, irradiation time, session frequency, treatment duration, and application mode, were exploratory.
Results:
Eighteen trials were included. PBMT/LLLT reduced pain (mean difference [MD] -1.09, 95% confidence interval [CI]: -1.60 to -0.57; I2 = 89%) and improved OHIP-14 (MD -3.82, 95% CI: -4.79 to -2.86; I2 = 41%). Xerostomia and depression were not significantly improved, whereas anxiety showed a modest reduction. Several irradiation protocol variables showed nominal exploratory signals.
Conclusions:
PBMT/LLLT may reduce BMS-related pain and improve oral-health-related quality of life. Current evidence supports irradiation protocol standardization but remains insufficient to define an optimal protocol.
