ESIC series, Paper 7: Capacity sharing in Evidence Synthesis: Recommendations from the Evidence Synthesis Infrastructure Collaborative (ESIC) Working group 5

To develop actionable recommendations for capacity sharing as a core enabler of a sustainable global evidence synthesis ecosystem.

The Evidence Synthesis Infrastructure Collaborative (ESIC), launched in 2024 with Wellcome Trust support, seeks to strengthen evidence synthesis methods, capacity, and infrastructure worldwide. Working Group 5 (WG5) focused on capacity sharing-defined as the equitable, reciprocal exchange of skills, knowledge, and resources-moving beyond traditional unidirectional capacity-building models to foster inclusive, collaborative approaches.

WG5 employed a two-phase, four-stage process informed by the Double Diamond design framework. Phase 1 mapped existing capabilities and gaps through a Capability Maturity Assessment across regions. Phase 2 identified and prioritized solutions via iterative consultations, literature reviews, expert feedback, and alignment with other ESIC working groups. Twenty participants from 22 countries contributed, ensuring diverse representation.

The Capability Maturity Assessment revealed stark disparities: high-income regions exhibited mature systems, while many LMICs lacked mechanisms for sustained collaboration. Barriers included fragmented digital infrastructure, skills gaps, weak mentorship, limited knowledge translation, and insufficient end-user engagement, with language as a cross-cutting challenge. WG5 proposed a portfolio of ten interlinked solutions, including an ESIC Knowledge Hub, knowledge translation tools powered by artificial intelligence, regional collaborating centers, mentorship programs, continuous professional development modules, and competency frameworks. These solutions aim to rebalance inequities, enhance efficiency, and foster south-led innovation.

WG5's recommendations provide a scalable, costed roadmap to embed equity and cocreation in global evidence synthesis. By integrating digital tools, human infrastructure, and participatory governance, the proposed portfolio offers funders and stakeholders a menu of options to transform a fragmented system into a connected, inclusive, and resilient evidence ecosystem.