Related Experiment Video
Updated: Sep 23, 2026

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma
Published on: November 4, 2010
[Role of energy metabolism in pediatric asthma]
E Celle1, T Trian1, P Esteves1
1Inserm, CRCTB, U 1045, université de Bordeaux, 33000 Bordeaux, France.
Abstract:
Asthma, which is the most common chronic respiratory disease in children, results from complex interactions between genetic factors, immune responses and environmental stimuli. Increasing evidence highlights energy metabolism and mitochondrial function as major contributors to the pathophysiology of pediatric asthma. Several mitochondrial genes have been identified as potential biomarkers associated with the disease, and at the cellular level, mitochondrial dysfunction has been linked to bronchial smooth muscle remodeling, one of the key aspects of disease severity. Taken together, these insights underscore the importance of characterizing energy metabolism and mitochondrial function in view of identifying new therapeutic targets for pediatric asthma.
Related Concept Videos
Asthma-II: Pathophysiology and Classification
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Asthma I: Introduction
Asthma: Pathogenesis and Management
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma-I: Introduction
Pharmacokinetics in Pediatric Patients: Drug Metabolism
Asthma-IV: Diagnostic and Management
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes: