Related Experiment Video
Updated: Sep 23, 2026
Single-Anastomosis Duodeno-Ileal Bypass with Sleeve Gastrectomy Model in Mice
Published on: February 10, 2023
Cost-effectiveness of endoscopic sleeve gastroplasty using a disease progression model
Junxing Chay1, Ravishankar Asokkumar2, Kwang Wei Tham3
1Programme in Health Services Research & Population Health, Duke-NUS Medical School, Singapore.
Background:
The clinical efficacy of endoscopic sleeve gastroplasty (ESG) is well established, yet evidence on its cost-effectiveness is limited.
Objectives:
This analysis assessed the lifetime cost-effectiveness of ESG and lifestyle management (ESG + lifestyle modification [LM]) compared with LM alone in ESG-eligible patients.
Setting:
Singapore health system perspective.
Methods:
We developed a Markov model to simulate the incidence of type 2 diabetes (T2D), stroke, myocardial infarction, and cardiovascular death. Disease risks were modeled as functions of age, sex, and key clinical risk factors. For each intervention arm, we simulated annual transitions between disease states, tracking associated healthcare costs and quality-adjusted life years (QALYs), both of which were discounted at an annual rate of 3%, over a lifetime horizon. We conducted one-way and probabilistic sensitivity analyses to assess the robustness of the results to changes in key model parameters.
Results:
The average cost of the ESG procedure in Singapore was SG$ 14,145 (US$ 10,590). In the base case (lifetime horizon), ESG + LM cost SG$ 9110 (US$ 6820) more and accrued .37 more QALYs than LM, generating an incremental cost-effectiveness ratio (ICER) of SG$ 24,580/QALY (US$ 18,410/QALY). The ICER for patients without T2D was SG$ 19,320/QALY (US$ 14,470/QALY). The ICER for patients with T2D was SG$ 37,320/QALY (US$ 27,950/QALY). At SG$ 75,000/QALY (US$ 56,170/QALY) threshold, ESG + LM was cost-effective in 98.8% of the probabilistic sensitivity analyses iterations.
Conclusions:
Over a lifetime horizon, ESG + LM is likely cost-effective for treating obesity in Singapore and may merit subsidy consideration for eligible patients.
