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Updated: Sep 23, 2026

System for Focal, Closed-System Central Nervous System Injury
Published on: November 29, 2024
Examining the Role of Behavioral Health Factors on Inpatient Traumatic Brain Injury Rehabilitation Outcomes Among
Justin T McDaniel1, Jolie N Haun2,3, Julie McMahon-Grenz2
1School of Human Sciences, College of Health and Human Sciences, Southern Illinois University, Carbondale, IL.
Objective:
To examine the association between behavioral health factors, specifically pretreatment alcohol and tobacco use, and traumatic brain injury (TBI)-related outcomes in the Intensive Evaluation and Treatment Program (IETP).
Design:
Retrospective longitudinal cohort design.
Setting:
The intervention and data collection were conducted at 5 Veterans Health Administration (VHA) sites (Florida, Texas, California, Minnesota, and Virginia).
Participants:
Behavioral health and TBI-related outcome data were collected from N=205 veteran and active-duty service member participants with mild-to-moderate TBI.
Interventions:
The VHA IETP delivered interdisciplinary rehabilitation to veterans and service members with a history of mild-to-moderate TBI and related conditions, including posttraumatic stress disorder (PTSD), pain, impaired function, and adverse neurobehavioral symptoms.
Main Outcome Measures:
The exploratory outcome measures included the Neurobehavioral Symptom Inventory, the PTSD Checklist for DSM-5, the Patient Reported Outcomes Measurement Information System Pain Interference scale, and the Mayo-Portland Adaptability Inventory. Pretreatment tobacco and alcohol use behaviors were extracted from patient medical records. Multiple linear regression models were fitted to the data to test our hypotheses.
Results:
Alcohol use was not shown to be associated with changes in any of the outcomes; however, tobacco use was associated with attenuated improvement in PTSD symptoms (p=.03).
Conclusions:
This study suggests that pretreatment tobacco use may lessen the effects of long-term PTSD rehabilitation among patients with TBI.
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