Related Experiment Videos
Insulin plus metformin for gestational diabetes mellitus: impacts on blood glucose, coagulation function, and
Yunping Wang1, Nianling Yao1, Lu Bai1
1Department of Obstetrics and Gynecology, Xijing Hospital, The Fourth Military Medical University Xi'an 710032, Shaanxi, China.
Objective:
This retrospective study focused on the impacts of insulin plus metformin (MET) on blood glucose (BG), coagulation function, and pregnancy outcomes in patients with gestational diabetes mellitus (GDM).
Methods:
The subjects were 129 GDM patients visiting The First Affiliated Hospital of Air Force Medical University, including 60 patients receiving insulin aspart (IA; control group) and 69 cases given MET+insulin aspart (observation group). General information and treatment outcomes were compared. Pre- and post-treatment BG (fasting plasma glucose [FPG], 2-hour postprandial plasma glucose [2hPG], glycosylated hemoglobin [HbA1c]), islet function (fasting insulin [FINS], Homeostasis Model Assessment-Insulin Resistance Index (HOMA-IR), HOMA-Beta Cell Function Index [HOMA-β]), coagulation function (activated partial thromboplastin time [APTT], prothrombin time [PT], thrombin time [TT]), adverse drug reactions, pregnancy outcomes, and fetal and neonatal conditions were compared between the two groups. Efficacy determinants were analyzed using univariate and multivariate methods.
Results:
Compared to controls, MET+IA-treated patients showed superior curative effects, lower post-treatment BG indexes, FINS, and HOMA-IR, higher HOMA-β and various coagulation function parameters, as well as reduced rates of overall adverse pregnancy outcomes, total neonatal adverse events, and macrosomia. The groups were comparable in the adverse drug reaction rate. An abortion history increased the risk of ineffective treatment.
Conclusion:
Insulin+MET benefits BG control, coagulation function, and pregnancy outcomes in GDM patients.
Related Concept Videos
Diabetes Mellitus: Type 2 and Gestational
Oral Hypoglycemic Agents: Biguanides and Glitazones
Pathophysiology of Diabetes
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility, suggesting a...
Dipeptidyl Peptidase 4 Inhibitors
Oral Hypoglycemic Agents: Glinides
Oral Hypoglycemic Agents: α-Glucosidase Inhibitors
Acarbose and miglitol are typically...