Related Experiment Video
Updated: Sep 23, 2026
Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation
Published on: July 16, 2014
Initial Experience with Pseudomonopolar Local Field Potentials in Deep Brain Stimulation for Parkinson's Disease
Loes Laurijssen1,2,3, Mathijs Meersman1, Wim Vandenberghe1,2
1Department of Neurosciences, Experimental Neurology, KU Leuven, Leuven, Belgium.
Background:
Local field potentials (LFPs) can assist DBS contact selection in Parkinson's disease (PD). To overcome the spatial uncertainty of bipolar recordings, pseudomonopolar recordings with an onboard algorithm have recently been introduced.
Objective:
To report initial experience with pseudomonopolar recordings.
Methods:
Pseudomonopolar recordings obtained during routine clinical care were retrospectively analyzed by a blinded rater. Potential reference-related electrical contamination was evaluated. The degree of agreement with the clinically optimized contact configuration was compared between visual power spectral density (PSD) and algorithm-based contact selection.
Results:
Among 97 hemispheres of 49 PD patients, 49.5% demonstrated clinically useful PSDs. PSDs were less often clinically useful when the contralateral reference contact had the highest beta activity. Agreement with clinically optimized contacts may be lower for the algorithm than for visual assessment.
Conclusions:
Pseudomonopolar recordings may facilitate PSD interpretation, but their referenced nature sometimes reduces reliability. Further evaluation of the onboard algorithm's performance is needed.
More Related Videos
10:46Acute In Vivo Electrophysiological Recordings of Local Field Potentials and Multi-unit Activity from the Hyperdirect Pathway in Anesthetized Rats
Published on: June 22, 2017
14:14Targeting Neuronal Fiber Tracts for Deep Brain Stimulation Therapy Using Interactive, Patient-Specific Models
Published on: August 12, 2018